Outcome Measures Used in Pediatric Stroke Studies A Systematic Review
- Abstract:
- Because no gold-standard outcome measure or measures exist to allow comparison of pediatric stroke study outcomes in clinical trials, we designed a systematic review of the literature to survey the current use of pediatric stroke outcome measures. Studies that used at least 1 standardized measure to assess the outcome of children with ischemic or hemorrhagic stroke, from full-term newborn to age 18 years, were included. Although 34 studies were included, an additional 36 studies could not be included because ad hoc, author-generated outcome measures were used. Excluding those measures in neuropsychological batteries, 38 unique outcome measures were used. The Wechsler Intelligence Scales, Pediatric Stroke Outcome Measure, and Bayley Scales of Infant Development were among the most used, but 79% of outcome measures were used by no more than 2 studies. Although many measures used have been validated for use in children with other medical conditions or for adults with stroke, only 1 measure has been specifically validated for use in pediatric ischemic stroke. To maximize comparability of future clinical trial results, agreement regarding a preferred pediatric stroke outcome scale or battery of measures is paramount; these measures should be reliable, responsive to change, and specifically validated for use in children with stroke
- DOI:
- DOI 10.1001/archneurol.2011.1015
- URL:
- <Go to ISI>://WOS:000298944500003
https://www.ncbi.nlm.nih.gov/pubmed/22232344 - Journal:
- Archives of Neurology
- issn:
- 0003-9942
- Publication year:
- 2012
- pages:
- 23-27
- Symptom status:
- Physical state
- Functional status:
- Cognitive/mental functioning
Physical functioning
Social functioning - Age:
- Children (0-18)
- Disease:
- Diseases of and symptoms related to the circulatory system
Diseases of and symptoms related to the nervous system - PRO / non-PRO:
- Non-patient Reported Outcome
Patient Reported Outcome - Type of measurement instrument:
- 1 - Questionnaires
4 - Performance-based tests
6 - Clinical rating scales
7 - Observations - Instrument:
- BSID - Bayley Scales of Infant Development (versions: BSID-4 - Toddler version)
CHQ - Child Health Questionnaire (versions: CHQ-SF; CHQ50)
CVLT-II - California Verbal Learning Test, Second edition
Denver Developmental Screening Tests
GMDS - Griffiths Mental Developmental Scales
GOS - Glasgow Outcome Scale
MRS - Modified Rankin Scale
Pediatric Stroke Outcome Measure
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]
| | also see: database.cosmin.nl
Stanford–Binet Intelligence Scale
VABS - Vineland Adaptive Behavior Scales (versions: VABS-I; VABS-II)
WIS-A - Wechsler Intelligence Scales for Adults
WISC-R - Wechsler Intelligence Scale for Children-Revised
WPPSI - Wechsler Preschool and Primary Scale of Intelligence (versions: WPPSI-R; WPPSI-III; WPPSI-IV)