COSMIN database

Quality of life in age-related macular degeneration: a review of available vision-specific psychometric tools

Finger, R. P., Fleckenstein, M., Holz, F. G., and Scholl, H. P.
PURPOSE: Age-related macular degeneration (AMD) has a considerable impact on older adults' independence and autonomy. Recently, patient reported outcomes (PROs) such as QoL have been met with increasing interest by the scientific community, healthcare payers and planners. Against this background, the multitude of psychometric tools used to measure QoL in AMD was reviewed.

METHODS: A search of the literature from 1990 onwards yielded 355 results, out of which 58 publications were included in the review. Data regarding design, validation and extent of utilization were obtained where available.

RESULTS: The National Eye Institute-Visual Function Questionnaire (NEI VFQ-25-item) was found to be the most often used (29% of studies) and best validated psychometric tool, followed by the Visual Function Questionnaire (VF-14; 17%), and the Impact of Vision Impairment Profile (IVI; 9%). Most tools that were identified have been validated for the use in AMD patients.

CONCLUSION: Psychometric tools specifically designed to measure vision-related quality of life are well equipped and validated to measure QoL in AMD. More recent developments such as the Macular Disease-dependent Quality of Life (MacDQoL) questionnaire might be able to depict dimensions of vision-related QoL in greater depth. Future studies should endeavour to use a suggested standard when gathering data on vision related QoL, allowing for international comparisons.
Qual Life Res
0962-9343 (Print)
Publication year:
Symptom status:
Emotional state
Physical state
Functional status:
Physical functioning
Role functioning
Social functioning
General health perceptions / HRQoL:
Health-related quality of life
Seniors (65+)
Diseases of and symptoms related to the eye and adnexa
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
2 - Interviews
ADVS - Activities of Daily Vision Scale
DLTV - Daily Living Tasks Dependent Upon Vision
IVI - Impact of Vision Impairment
McDQoL - Macular Disease Quality of Life questionnaire
NEI VFQ - National Eye Institute Visual Function Questionaire (versions: NEI VFQ-9 items)
VF-14 - Visual Function Index-14