COSMIN database

A review of quality of life instruments used in liver transplantation

Authors:
Jay, C. L., Butt, Z., Ladner, D. P., Skaro, A. I., and Abecassis, M. M.
Abstract:
With improvements in patient and graft survival after liver transplantation, recipient quality of life (QOL) has become an important focus of patient care and clinical outcomes research. To provide a better understanding of the instruments used to assess QOL in the adult liver transplant population, we conducted a systematic review of the MEDLINE database and Cochrane library. Our review identified 128 relevant articles utilizing more than 50 different QOL instruments. Generic health status instruments are the most commonly used, and among them the Medical Outcomes Study Short Form-36 (SF-36), the Hospital Anxiety and Depression Scale (HADS), and the Beck Depression Inventory (BDI) are the most prevalent. Few studies (16%) included targeted, disease-specific instruments. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Quality of Life questionnaire, the Liver Disease Quality of Life questionnaire, and the Chronic Liver Disease questionnaire are the most frequently employed targeted instruments; however, these instruments have been designed to assess QOL in patients with chronic liver disease rather than patients after liver transplantation. The present review focuses on the psychometric properties of the existing QOL instruments and discusses their individual strengths and limitations in evaluating liver transplantation recipients. The lack of a gold-standard QOL instrument for liver transplant recipients is an impediment to cross-study comparisons. We conclude that the development of a QOL instrument specifically for liver transplant recipients will improve QOL assessment in this population leading to a more nuanced understanding of the factors that influence transplant recipients' well-being. (C) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
DOI:
10.1016/j.jhep.2009.07.010
URL:
<Go to ISI>://WOS:000271760800015
https://www.ncbi.nlm.nih.gov/pubmed/19775771
Journal:
Journal of Hepatology
issn:
0168-8278
Publication year:
2009
pages:
949-959
Symptom status:
Cognitive/mental state
Emotional state
Physical state
Functional status:
Cognitive/mental functioning
Physical functioning
Role functioning
Social functioning
Overall quality of life:
Overall quality of life
Age:
Adults (18-65)
Seniors (65+)
Disease:
Diseases of and symptoms related to the digestive system
Factors influencing health status and contact with health services
Injury, poisoning and certain other consequences of external causes
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
Instrument:
BDI - Beck Depression Inventory   [see: ZUYD (NL)]
CLDQ - Chronic Liver Disease Questionnaire
EQ-5D - EuroQoL-5 Dimensions   [see: ZUYD (NL)]
HADS - Hospital Anxiety and Depression Scale   [see: ZUYD (NL)]
LDQOL - Liver Disease Quality of Life questionnaire
NIDDK-QA - National institute of diabetes and digestive and kidney disease liver transplant questionnaire
SF-36 - 36-item Short Form Health Survey   [see: proqolid, ZUYD (NL)]
SIP - Sickness Impact Profile   [see: ZUYD (NL)]