Thyroid disease-specific quality of life questionnaires - A systematic review

Authors:

Uslar, V., Becker, C., Weyhe, D., and Tabriz, N.

Abstract:

INTRODUCTION: Thyroid diseases are very common and rarely life-threatening. One of the main therapeutic goals is an improvement in quality of life, making it important to measure in clinical and research settings. The aim of this systematic review is to provide an overview of the currently available thyroid-specific quality of life questionnaires with regard to their validation quality in order to make recommendations for clinical use with a special focus on German questionnaires.

METHODS: A systematic literature search was performed in Pubmed, Google Scholar and the Cochrane Library. A total of 904 studies were identified. After excluding duplicates, non-English- or German-language texts, full texts that were not freely available and studies with irrelevant content, 64 studies reporting on 16 different questionnaires were included in the analysis.

RESULTS: Four questionnaires concerned benign thyroid diseases (ThyPRO, ThyPRO-39, Thy-R-HRQoL and Thy-D-QOL), six malignant thyroid diseases (THYCA-QoL, ThyCa-HRLQOL, EORTC-Thy34, MADSI-Thy, QOL-Thyroid and ThyCAT), and six endocrine orbitopathy (GO-QOL, GO-QLS, TED-QOL, STED-QOL, TAO-QoL and Ox-TED). Only five questionnaires were at least developed, if not validated, in German, and five were developed in more than two languages.

CONCLUSIONS: ThyPRO and the ThyPRO-39 are the best-evaluated questionnaires for benign thyroid diseases. Alternatively, in hypothyroid patients, the adequately validated Thy-D-QoL can be used. For malignant thyroid diseases, the choice should be made individually, as all six questionnaires (THYCA-QoL, ThyCA-HRQOL, EORTC-Thy34, MDASI-Thy, QOL-Thyroid and ThyCAT) have different strengths and weaknesses. The GO-QOL is the best-validated questionnaire in endocrine orbitopathy. However, the TED-QOL is also suitable as a short-screening questionnaire for these patients.

DOI:

10.1002/edm2.357

URL:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471597/pdf/EDM2-5-e357.pdf

Journal:

Endocrinol Diabetes Metab

issn:

2398-9238

Publication year:

2022

pages:

e357

General health perceptions / HRQoL:

Health-related quality of life

Overall quality of life:

Overall quality of life

Age:

Adults (18-65)
Children (0-18)
Seniors (65+)

Disease:

Endocrine, nutritional and metabolic diseases and related symptoms
Neoplasms and related symptoms

PRO / non-PRO:

Patient Reported Outcome

Type of measurement instrument:

1 - Questionnaires

Instrument:

EORTC QLQ-THY - European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Thyroid Cancer Module (EORTC QLQ-THY34)
GO- QLS - Graves' Ophthalmopathy Quality of Life Scale
GO-QOL - Graves’ Ophthalmopathy-specific Quality of Life
HCQ - Hyperthyroid Complaint Questionnaire
HPQ-40/28 - Hypothyroidism Questionnaire-40/28
MDASI-THY - MD Anderson Symptom Inventory-Thyroid Cancer module
Ox-TED - Oxford Thyroid Eye Disease Quality of Life Score
QOL-Thyroid - Quality of Life - Thyroid
TAO-QoL - Thyroid Associated Ophthalmology Quality of Life
TED-QOL - Thyroid Eye Disease Quality of Life (versions: STED-QoL - Singapore TED-QOL)
THYCA-QoL - Thyroid Cancer-specific Quality of Life questionnaire
ThyCAT - Thyroid cancer Quality of Life Computerized Adaptive Test
Thy-D-QoL - Thyroid- Dependent Quality of Life Questionnaire
ThyPRO - Thyroid-specific Patient-Reported Outcome measure (versions: ThyPRO-39)
Thy- R- HRQoL - Thyroid- Related Health- Related Quality of Life
ThySRQ - (Underactive) Thyroid Symptom Rating Questionnaire
ThyTSQ - Thyroid Treatment Satisfaction Questionnaire