COSMIN database

Quality of life in venous disease

van Korlaar, I., Vossen, C., Rosendaal, F., Cameron, L., Bovill, E., and Kaptein, A.
Quality of life (QOL) can be defined as the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient. Studies on the impact of chronic venous disease on quality of life are scarce compared to quality of life research in other diseases. The purpose of this paper was to describe instruments that assess the quality of life in patients with chronic venous disease and to review the literature on this topic. A computer search of the MedLine database was performed to identify papers; the bibliographies of relevant articles were reviewed to obtain additional papers. Papers were included if they described the development or use of a quality of life instrument for patients with chronic venous disease. A total of 25 papers were identified that fit the inclusion criteria. The studies described in the papers used six different generic instruments and ten disease-specific instruments. Quality of life in chronic venous disease was assessed in 12 studies. Six studies compared different types of treatment for chronic venous disease where QOL was an outcome measure. Despite the wide variety of measures used, results indicate that the quality of life of patients with chronic venous disease is affected in the physical domain mostly with regard to pain, physical functioning and mobility, and that they suffer from negative emotional reactions and social isolation. We feel that QOL should be a standard measure in future studies in patients with chronic venous disease, preferably with a combination of generic and disease-specific measures.
Thromb Haemost
0340-6245 (Print)
Publication year:
General health perceptions / HRQoL:
Health-related quality of life
Overall quality of life:
Overall quality of life
Adults (18-65)
Seniors (65+)
Diseases of and symptoms related to the circulatory system
PRO / non-PRO:
Non-patient Reported Outcome
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
2 - Interviews
6 - Clinical rating scales
Charing Cross Venous ulcer Questionnaire
CIVIQ - Chronic Lower Limb Venous Insufficiency Questionnaire
Clinical Varicose-Veins Questionnaire
EQ-5D - EuroQoL-5 Dimensions   
FAI - Frenchay Activities Index   
FLQA - Freiburg Life Quality Assessment [Alias: FLQA - Freiburger Questionnaire of QOL in venous diseases ]
Health questionnaire for leg ulcers
Health Questionnaire for venous desease
Health-related Quality of life questionnaire for deep vein trombosis
NHP - Nottingham Health Profile   
Self-report QOL Questionnaire for patients with leg ulcers
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]    |  | also see:
SF-MPQ - McGill Short Form Pain Questionnaire
SRT - Symptom Rating Test
TLQ-CVI - Tübingen Questionnaire for measuring quality of life of patients with chronic venous insufficiency
VEINES-QoL/Sym - Venous Insufficiency Epidemiological and Economic Study Questionnaire