COSMIN database

A review of the health-related quality of life literature in bipolar disorder

Namjoshi, M. A. and Buesching, D. P.
This paper reviews the existing literature on health-related quality of life assessments conducted in bipolar disorder patients, and provides recommendations for the use of specific scales to measure health-related quality of life in this population. A comprehensive review of the literature revealed only a handful of studies in bipolar disorder that had incorporated quality of life assessments. While instruments from the medical outcomes study (MOS) were the most frequently used to measure health-related quality of life, a number of other instruments like the psychological general well being scale (PGWB), the streamlined longitudinal interview clinical evaluation from the longitudinal interval follow-up evaluation (SLICE/LIFE), the Euroqol, (EQ-5D), the Lehman's quality of life interview (QLI), and the quality of life in depression scale (QLDS) were also used. Only three studies out of ten reported the psychometric properties of the measures used. In the absence of a disease-targeted measure, a combination of the SF-36 and the PGWB is presently recommended as the battery of choice to assess the health-related quality of life of individuals with bipolar disorder. There is also the need to develop a disease-targeted health-related quality of life measure for bipolar disorder, which will obviate the use of a burdensome battery of generic quality of life instruments.
Qual Life Res
0962-9343 (Print)
Publication year:
Functional status:
Cognitive/mental functioning
General health perceptions / HRQoL:
Health-related quality of life
Adults (18-65)
Seniors (65+)
Certain conditions originating in the perinatal period and related symptoms
Mental and behavioural disorders and related symptoms
PRO / non-PRO:
Non-patient Reported Outcome
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
2 - Interviews
6 - Clinical rating scales
EQ-5D - EuroQoL-5 Dimensions   
GARF - Global Assessment of Relational Functioning
HAM-D - Hamilton Rating Scale for Depression [alias: HDRS][alias: HRSD]   
MHI - Mental Health Inventory (verisons: MHI-5 ; MHI-5 items; MHI-38 - MHI 38 items)
MOS-CFS - Medical Outcome Study Cognitive Function Scale
PGWBI - Psychological General Well-Being index [alias: PGWB] (Also: PGWBI-S - short form)
QLDS - Quality of Life in Depression Scale
QLI 3.0 - Quality of Life Index 3.0
QOLI - Lehman Quality of Life Interview/Index
SBQOL - SmithKline Beecham Quality of Life Instrument
SF-12 - 12-item Short Form Health Survey [alias: RAND-12]
SF-20 - MOS short-form general health survey 20 item
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]    |  | also see:
SLICE/LIFE - Streamlined Longitudinal Interiew Clinical Evaluation from the Longitudinal Interval Follow-up Evaluation
YMRS - Young Mania Rating Scale