COSMIN database

Measuring symptoms in localized prostate cancer: a systematic review of assessment instruments

Rnic, K., Linden, W., Tudor, I., Pullmer, R., and Vodermaier, A.
It is critical for prostate cancer researchers and clinicians to have access to comprehensive, sensitive and simple-to-use symptom measures that allow them to understand and quantify the subjective patient experience. The purpose of the current review is to provide a comprehensive review, detailed tool descriptions and objectively defined quality criteria to facilitate tool choices for patients with localized prostate cancer. Using a systematic web-based literature search, we found n=29 prostate symptom measures described in n=35 validation studies. To be recommended, tools needed to meet four criteria: broad domain coverage, ability to differentiate objective and subjective experience, good internal consistency and validation in at least two populations and/or having achieved two types of validations. Of the 29 tools reviewed, n=7 meet our criteria for recommendation, and three in particular (the EPIC-26 (Expanded Prostate Cancer Index Composite)-26, PC-QOL (Prostate Cancer-Quality of Life) and the UCLA-PCI (UCLA Prostate Cancer Index)) showed the strongest psychometrics. There is a reasonable number of measures to choose from that meet criteria for good psychometrics.
Prostate Cancer Prostatic Dis
1476-5608 (Electronic)
Publication year:
Symptom status:
Emotional state
Physical state
Functional status:
Physical functioning
Role functioning
Social functioning
General health perceptions / HRQoL:
Health-related quality of life
Overall quality of life:
Overall quality of life
Adults (18-65)
Seniors (65+)
Diseases of and symptoms related to the genitourinary system
Neoplasms and related symptoms
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
EORTC QLQ-PR25 - European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire in patients with prostate cancer 25 item
EPIC - Expanded Prostate Cancer Index Composite (versions: EPIC-26; EPIC-50; EPIC-SB; EPIC-CP)
ESCAP-CDV - Estudio sobre la Calidad de Vida en el Cáncer de Próstata- Calidad de Vida
European Quality of Life Questionnaire
FACT-Advanced Prostate Symptom Index-8 - Functional Assessment of Cancer Therapy Advanced Prostate Symptom Index-8 items
FACT-P - Functional Assessment of Cancer Therapy Prostate
FACT-P Symptom Index-17 - Functional Assessment of Cancer Therapy Prostate Symptom Index-17 items
IPSS - International Prostate Symptom Score   
Late effects of normal tissue
Male Urogenital Distress Inventory
PC-QoL - Prostate Cancer Quality of Life
PCSI - Prostate Cancer-Specific Instrument OR: Prostate Cancer Symptom Indices
PORPUS - Patient-Oriented Prostate Utility Scale
PROSQOLI - Prostate Cancer- Specific QOL Instrument
Prostate Cancer Symptom Scale [alias: QUFW94]
Prostate Cancer Treatment Outcome Questionnaire
Prostatectomy Therapy Survey Instruments
Prostate Symptom Self-Report
PSM - German Prostate Specific Module
Radiation Adverse Effect QOL Tool
Radiumhemmets Scale of Disease-Specific Symptom Assessment-Prostate Cancer;
Symptom Index
Symptom Indexes
Symptom Scale
UCLA-PCI - University of California Los Angeles-Prostate Cancer Index