COSMIN database

Which quality of life score is best for glaucoma patients and why?

Severn, P., Fraser, S., Finch, T., and May, C.
BACKGROUND: The glaucomas are generally asymptomatic diseases until they are very advanced. They affect 2% of the population over 40 years of age and therefore represent a significant public health issue. There have been a number of attempts to develop quality of life scales for the disease. This review discusses the pros and cons of these scales and suggests the best of the current ones for use in a clinical setting.

METHODS: Medline, Embase and Google Scholar were searched for relevant articles. No time period was defined and all types of article were included.

RESULTS: 11 Quality of Life scores were identified that have been used with glaucoma patients.

CONCLUSION: There is no generally accepted 'best' Quality of Life instrument for use in glaucoma. Many of the scales are biased towards physical symptoms and do little to address the personal or social factors of the disease. Further work is needed to produce scales that address all these areas as well as being simple to administer in a clinical setting
BMC Ophthalmol.
Publication year:
Symptom status:
Cognitive/mental state
Emotional state
Physical state
Functional status:
Physical functioning
Role functioning
Social functioning
General health perceptions / HRQoL:
Health-related quality of life
Adults (18-65)
Seniors (65+)
Diseases of and symptoms related to the eye and adnexa
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
ADVS - Activities of Daily Vision Scale
COMTOL - Comparison of Ophthalmic Medication for Tolerability
GHPI - Glaucoma Health Perceptions Index
GQL-15 (Also GQL-36 or GLAU-QOL36) - Glaucoma Quality of Life-15 (Glaucoma Quality of Life-36)
GSS - Glaucoma Symptom Scale
NEI VFQ-25 - 25-item National Eye Institute Visual Function Questionnaire
NEI VFQ - National Eye Institute Visual Function Questionaire (versions: NEI VFQ-9 items)
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]    |  | also see:
SIG - Symptom Impact Glaucoma Score
SIP - Sickness Impact Profile (versions: SIP-8; SIP-68; SIP-136; SIP-SV; UKSIP)   
VF-14 - Visual Function Index-14 (versions: VF-7)