Proxy-reported questionnaires for young children with asthma: a structured review

Authors:

Barrett, A., Clark, M., Demuro, C., and Esser, D.

Abstract:

Which proxy-reported outcome measures have been developed for use with children aged 6 years and younger to assess asthma symptoms, asthma control, and asthma-specific health-related quality of life, and do these questionnaires' measurement properties support their use as end-points in clinical trials? A two-phase literature search was conducted: 1) studies describing relevant questionnaires were identified, and the questionnaires were assessed against predefined criteria; 2) studies providing information on the measurement properties of questionnaires meeting the predefined inclusion criteria were identified. Literature sources included PubMed and EMBASE databases, scientific conference proceedings, a clinical trial registry, and a quality of life instrument database. The initial search of literature databases and conference abstracts identified 631 records. 20 paediatric asthma proxy-reported outcome instruments were identified; seven met the inclusion criteria: Childhood Asthma Control Test, Control de Asma en Ninos Questionnaire, Pediatric Asthma Caregiver Diary, Pediatric Asthma Control Tool, PedsQL 3.0 Short-Form 22 Asthma Module, PedsQL Asthma Symptoms Scale, and Test for Respiratory and Asthma Control in Kids. Three proxy-reported outcome instruments were considered suitable for use as end-points in paediatric asthma clinical trials; the Pediatric Asthma Caregiver Diary possesses the strongest measurement properties of the three.

DOI:

10.1183/09031936.00052112

URL:

https://www.ncbi.nlm.nih.gov/pubmed/23143547

Journal:

Eur Respir J

issn:

1399-3003 (Electronic)

Publication year:

2013

pages:

513-26

Symptom status:

Physical state

Functional status:

Physical functioning

General health perceptions / HRQoL:

Health-related quality of life

Age:

Children (0-18)

Disease:

Diseases of and symptoms related to the respiratory system

PRO / non-PRO:

Non-patient Reported Outcome

Type of measurement instrument:

1 - Questionnaires
3 - Diaries
7 - Observations

Instrument:

C-ACT - Childhood Asthma Control Test
CAN - Control de Asma en Niños
PACD - Pediatric Asthma Caregiver Diary
PACT - Pediatric Asthma Control Tool
PedsQL 3.0 - Pediatric Quality of Life Inventory
PedsQL 3.0 SF22-Asthma Module - a short form of the PedsQL 3.0 Asthma Module
PedsQL-Asthma - Pediatrics Quality of Life-Asthma Module
TRACK - Test for Respiratory and Asthma Control in Kids