COSMIN database

Pain after spinal cord injury: an evidence-based review for clinical practice and research. Report of the National Institute on Disability and Rehabilitation Research Spinal Cord Injury Measures meeting

Bryce, T. N., Budh, C. N., Cardenas, D. D., Dijkers, M., Felix, E. R., Finnerup, N. B., Kennedy, P., Lundeberg, T., Richards, J. S., Rintala, D. H., Siddall, P., and Widerstrom-Noga, E.

OBJECTIVES: To examine the reliability, validity, sensitivity, and practicality of various outcome measures for pain after spinal cord injury (SCI), and to provide recommendations for specific measures for use in clinical trials.

DATA SOURCES: Relevant articles were obtained through a search of MEDLINE, EMBASE, CINAHL, and PubMed databases from inception through 2006.

STUDY SELECTION: The authors performed literature searches to find articles containing data relevant to the reliability and validity of each pain outcome measure in SCI and selected non-SCI populations.

DATA EXTRACTION: After reviewing the articles, an investigator extracted information utilizing a standard template. A second investigator reviewed the chosen articles and the extracted pertinent information to confirm the findings of the first investigator.

DATA SYNTHESIS: Taking into consideration both the quantity and quality of the studies analyzed, judgments on reliability and validity of the measures were made by the two investigators. Based upon these judgments, recommendations were formulated for use of specific measures in future clinical trials. In addition, for a subset of measures a voting process by a larger group of SCI experts allowed formulation of recommendations including determining which measures should be incorporated into a minimal dataset of measures for clinical trials and which ones need revision and further validity and reliability testing before use.

CONCLUSIONS: A 0-10 Point Numerical Rating Scale (NRS) is recommended as the outcome measure for pain intensity after SCI, while the 7-Point Guy/Farrar Patient Global Impression of Change (PGIC) scale is recommended as the outcome measure for global improvement in pain. The SF-36 single pain interference question and the Multidimensional Pain Inventory (MPI) or Brief Pain Inventory (BPI) pain interference items are recommended as the outcome measures for pain interference after SCI. Brush or cotton wool and at least one high-threshold von Frey filament are recommended to test mechanical allodynia/hyperalgesia while a Peltier-type thermotester is recommended to test thermal allodynia/hyperalgesia. The International Association for the Study of Pain (IASP) or Bryce-Ragnarsson pain taxonomies are recommended for classification of pain after SCI, while the Neuropathic Pain Scale (NPS) is recommended for measuring change in neuropathic pain and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) for quantitating neuropathic and nociceptive pain discrimination.
J Spinal Cord Med
1079-0268 (Print)
Publication year:
Symptom status:
Physical state
Adults (18-65)
Children (0-18)
Seniors (65+)
Diseases of and symptoms related to the musculoskeletal system and connective tissue
Injury, poisoning and certain other consequences of external causes
PRO / non-PRO:
Non-patient Reported Outcome
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
6 - Clinical rating scales
9 - Laboratory tests
BPI - Brief Pain Inventory
CPGQ - Chronic pain Grading Questionnaire
CSQ - Coping Strategies Questionnaire
DN-4 - Douleur Neuropathique 4 Questions (Neuropathic Pain 4 Questions)
Guy/Farrar-PGIC - Guy/Farrar (Patient) Global Impression of Change scales
LANSS - Leeds Assessment of Neuropathic Symptoms and Signs
LF-MPQ - McGill Pain Questionnaire long-form
Modular Sensory Analyzer Thermotest (Somedic; Sweden)
MPI Life Interference subscale
MPI - Multidimensional Pain Inventory   Logozuyd
MPI-SCI - Multidimensional Pain Inventory Spinal Cord Injury
MPQ - McGill Pain Questionnaire    Logozuyd
NPQ (-SF) - Neuropathic Pain Questionnaire (-Short-Form)
NPSI - Neuropathic Pain Symptom Inventory
NPS - Neuropathic Pain Scale
NPS-R - Neuropathic Pain Scale Revised,
NRS - Numeric Rating Scale [alias: NPRS - Numeric Pain Rating Scale]   Logozuyd
PQAS - Pain Quality Assessment Scale
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]   Proqolid blue crop | Logozuyd | also see:
SF-MPQ - McGill Short Form Pain Questionnaire
S-LANSS - self-completed version of the Leeds Assessment of Neuropathic Symptoms
SWM - Semmes Weinstein Monofilaments   Logozuyd
Thermal stimulus
TSA II Neurosensory Analyzer (Medoc, Ltd; Israel)
VAS - Visual Analogue Scale   Logozuyd
Von Frey filaments
VRS - Verbal (Pain) Rating Scale