COSMIN database

A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies

Chan, A., Cameron, M. C., Garden, B., Boers-Doets, C. B., Schindler, K., Epstein, J. B., Choi, J., Beamer, L., Roeland, E., Russi, E. G., Bensadoun, R. J., Teo, Y. L., Chan, R. J., Shih, V., Bryce, J., Raber-Durlacher, J., Gerber, P. A., Freytes, C. O., Rapoport, B., LeBoeuf, N., Sibaud, V., and Lacouture, M. E.
PURPOSE: Dermatologic adverse events (dAEs) in cancer treatment are frequent with the use of targeted therapies. These dAEs have been shown to have significant impact on health-related quality of life (HRQoL). While standardized assessment tools have been developed for physicians to assess severity of dAEs, there is a discord between objective and subjective measures. The identification of patient-reported outcome (PRO) instruments useful in the context of targeted cancer therapies is therefore important in both the clinical and research settings for the overall evaluation of dAEs and their impact on HRQoL.

METHODS: A comprehensive, systematic literature search of published articles was conducted by two independent reviewers in order to identify PRO instruments previously utilized in patient populations with dAEs from targeted cancer therapies. The identified PRO instruments were studied to determine which HRQoL issues relevant to dAEs were addressed, as well as the process of development and validation of these instruments.

RESULTS: Thirteen articles identifying six PRO instruments met the inclusion criteria. Four instruments were general dermatology (Skindex-16(c), Skindex-29(c), Dermatology Life Quality Index (DLQI), and DIELH-24) and two were symptom-specific (functional assessment of cancer therapy-epidermal growth factor receptor inhibitor-18 (FACT-EGFRI-18) and hand-foot syndrome 14 (HFS-14)).

CONCLUSIONS: While there are several PRO instruments that have been tested in the context of targeted cancer therapy, additional work is needed to develop new instruments and to further validate the instruments identified in this study in patients receiving targeted therapies.
Support Care Cancer
1433-7339 (Electronic)
Publication year:
Symptom status:
Emotional state
Physical state
Functional status:
Physical functioning
Role functioning
Social functioning
General health perceptions / HRQoL:
Health-related quality of life
Adults (18-65)
Diseases of and symptoms related to the skin and subcutaneous tissue
Neoplasms and related symptoms
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
DIEHL - Deutsches Instrument zur Erfassung der Lebensqualität bei Hauterkrankungen (German Instrument for the Assessment of Quality of Life in Skin Diseases) (versions: DIEHL-24)
DLQI - Dermatology Life Quality Index   
FACT-EGFRI-18 - Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitors-18
HFS-14 - Hand-foot Syndrome Specific QoL Questionnaire-14