COSMIN database

Instruments for Assessing Chemotherapy-Induced Peripheral Neuropathy: A Review of the Literature

Curcio, K. R.
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often dose-limiting side effect of chemotherapy that can result in disability and poorer quality of life. However, no standardized measurement for CIPN exists. Clinicians often base decisions for dose modification or discontinuation of a chemotherapeutic agent on patient report of subjective symptoms and physical examination.

OBJECTIVES: This review is designed to identify valid and reliable assessment tools that measure or assess CIPN in adult patients receiving chemotherapy.

METHODS: A systematic literature review was conducted using PubMed, CINAHL(R), and Cochrane Library. Articles were included if their primary purpose was to evaluate the psychometric properties of scales to measure CIPN in adult patients with cancer receiving neurotoxic chemotherapeutic agents.

FINDINGS: The search yielded 143 results, with 16 articles meeting criteria for inclusion in the review. Seven unique scales and their reduced and modified versions were examined. The majority of the questionnaires were evaluated in a single tumor type, primarily with taxanes and platinum compounds. No consensus exists on the most appropriate patient self-report scale for use in the general oncology population.
Clin J Oncol Nurs
Publication year:
Biological and physiological variables:
Biological and physiological variables
Symptom status:
Emotional state
Physical state
Functional status:
Physical functioning
Role functioning
General health perceptions / HRQoL:
Self-rated health
Overall quality of life:
Overall quality of life
Adults (18-65)
Seniors (65+)
Diseases of and symptoms related to the nervous system
Neoplasms and related symptoms
PRO / non-PRO:
Non-patient Reported Outcome
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
6 - Clinical rating scales
CIPN - Chemotherapy-induced Peripheral Neuropathy Assessment Tool [alias: CIPNAT]
EORTC QLQ-CIPN20 - European Organization of Research and Treatment of Cancer Quality of Life-Chemotherapy-Induced Peripheral Neuropathy   
FACT/GOG-Ntx - Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (versions: FACT/GOG-Ntx12)
FACT/GOG-Taxane - Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Taxane   
mTNS - modified Total Neuropathy Score
PNQ - Patient Neurotoxicity Questionnaire
PNS - Peripheral Neuropathy Scale
SCIN - Scale for Chemotherapy-Induced Long Term Neurotoxicity
TNSc - Total Neuropathy Score-clinical
TNSr-SF - Total Neuropathy Score-reduced short form
TNSr - Total Neuropathy Score-reduced
TNS - Total Neuropathy Score