COSMIN database

Choosing appropriate patient-reported outcomes instrument for glaucoma research: a systematic review of vision instruments

Che, Hamzah J., Burr, J. M., Ramsay, C. R., zuara-Blanco, A., and Prior, M.
PURPOSE: To identify vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity.

METHODS: MEDLINE, MEDLINE in Process, EMBASE and SCOPUS (to January 2009) were systematically searched. Observational studies or randomised controlled trials, published in English, reporting use of vision instruments in glaucoma studies involving adults were included. In addition, reference lists were scanned to identify additional studies describing development and/or validation to ascertain the final version of the instruments. Instruments' content was then mapped onto a theoretical framework, the World Health Organization International Classification of Functioning, Disability and Health. Two reviewers independently evaluated studies for inclusion and quality assessed instrument content.

RESULTS: Thirty-three instruments were identified. Instruments were categorised into thirteen vision status, two vision disability, one vision satisfaction, five glaucoma status, one glaucoma medication related to health status, five glaucoma medication side effects and six glaucoma medication satisfaction measures according to each instruments' content. The National Eye Institute Visual Function Questionnaire-25, Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment.

CONCLUSION: This study provides a descriptive catalogue of vision-specific PRO instruments, to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Qual Life Res
Publication year:
Symptom status:
Physical state
Functional status:
Physical functioning
General health perceptions / HRQoL:
Health-related quality of life
Self-rated health
Adults (18-65)
Seniors (65+)
Diseases of and symptoms related to the eye and adnexa
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
2 - Interviews
Abelson instrument
ADVS - Activities of Daily Vision Scale
Catquest (versions: Catquest-9SF)
CES-D - Centre for Epidemiologic Studies-Depression Scale   
CIGTS QOL instrument Collaborative Initial Glaucoma Treatment Study Quality of Life instrument
Comorbidity Bothersome Score
COMTOL - Comparison of Ophthalmic Medication for Tolerability
Dunker instrument
EDSQ - Eye Drop Satisfaction Questionnaire
Ellwein instrument
Eye Medication Treatment Questionnaire
GDI - Glaucoma Disability Index
Generic Health Perception
GHPI - Glaucoma Health Perceptions Index
GSS - Glaucoma Symptom Scale
Haverkamp instrument
IND-VFQ (Also IND-VFQ33) - Indian visual function questionnaire (Also: Indian visual function questionnaire 33)
Ivers instrument
IVI - Impact of Vision Impairment
Lee instrument
LVQOL - Low Vision Quality Of Life questionnaire
Mills instrument (adapted by Viswanathan)
NEI VFQ-25 - 25-item National Eye Institute Visual Function Questionnaire
NEI VFQ - National Eye Institute Visual Function Questionaire (versions: NEI VFQ-9 items)
Noecker instrument
Odberg instrument
OSDI - Ocular Surface Disease Index (and Modified OSDI; 10 item version)
QLVFQ - Quality of Life and Vision Function Questionnaire
Ross instrument
Shibuya instrument
SHPC - Symptom and Health Problem Checklist
SIP - Sickness Impact Profile   
SQOL DVI - Scale of QOL for Disease with Visual Impairment
Sumi instrument
TSS-IOP - Treatment Satisfaction Survey-Intraocular Pressure
Turano’s instrument
Uenishi instrument
VALDA - Vision associated limitations in daily activities
VAQ - Visual Activities Questionnaire
VCM1 - Core Questionnaire of Vision-Related Quality Of Life Measure
VF-14 - Visual Function Index-14