COSMIN database

A systematic review of health-related quality of life and psychological outcomes after lung transplantation

Seiler, A., Klaghofer, R., Ture, M., Komossa, K., Martin-Soelch, C., and Jenewein, J.
BACKGROUND: Lung transplantation (LTx) aims to reduce physical disability and mental distress, extend survival, and improve health-related quality of life (HRQoL). In this systematic review we aimed to: (1) augment evidence regarding measures to assess HRQoL and psychological outcomes after LTx; and (2) summarize HRQoL and psychological outcomes after LTx.

METHODS: Validated and standardized instruments with well-known psychometric properties used for assessing HRQoL and psychological outcomes after LTx were identified by means of comprehensive literature searches of PsychINFO and Medline/PubMed, up through March 2014, using the following search terms in various combinations: lung transplantation; physical functioning; symptom experience; mental health; anxiety; depression; distress; social functioning; life satisfaction; and health-related quality of life.

RESULTS: The search strategy identified 371 titles and abstracts. Of these, 279 were retrieved for further assessment and 63 articles selected for final review. Thirty-nine studies were found for HRQoL, 15 for physical functioning, 5 for mental health and 4 for social functioning. A total of 50 psychometric instruments were encountered.

CONCLUSIONS: Considerable heterogeneity exists in methodology, operational concepts and applied outcome measures in the existing literature on HRQoL and psychological outcomes after LTx. Nevertheless, the studies generally point to significant improvements in both mental health and HRQoL post-transplant. Further research is warranted utilizing consistent outcome measures, including LTx-specific measures and longitudinal study designs.
J Heart Lung Transplant
Publication year:
Symptom status:
Cognitive/mental state
Emotional state
Functional status:
Cognitive/mental functioning
Physical functioning
Social functioning
General health perceptions / HRQoL:
Health-related quality of life
Overall quality of life:
Overall quality of life
Adults (18-65)
Diseases of and symptoms related to the respiratory system
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
BAI - Beck Anxiety Inventory
BCSC - Body Cathexis Scale
BDI - Beck Depression Inventory   
BPI - Basic Personality Inventory
BPI - Brief Pain Inventory
BSI - Brief Symptom Inventory
CES-D - Centre for Epidemiologic Studies-Depression Scale   
DAS - Dyadic Adjustment Scale
DSFI - Derogatis Sexual Functioning Inventory
Dyspnea Assessment with visual analogue scale
EQ-5D - EuroQoL-5 Dimensions   
FLZ - Fragen zur Lebenszifriedenheit (Questions on Life Satisfaction)
F-SoZu - Evaluation of the short-form social support questionnaire (Also: F-SoZu-K22 - short version)
GHQ - General Health Questionnaire
HADS - Hospital Anxiety and Depression Scale   
HUI-3 - Health Utilities Index-Mark 3
IIRS - Illness Intrusion Rating Scale
IWB - Index of Well-Being
Katz ADL - Katz’ Index Of Independence In Activities Of Daily Living    | 
KPS - Karnofsky Performance Scale (of: Status)
LOT - The Life Orientation Test
MHI - Mental Health Inventory (verisons: MHI-5 ; MHI-5 items; MHI-38 - MHI 38 items)
MHLC - Multidimensional Health Locus of Control Scale   
MOS-20 - 20-Item Medical Outcome Study Short-Form General Health Survey
MPQ - McGill Pain Questionnaire    
MTSOSD-59R - Modified Transplant Symptom Occurrence and Distress Scale 59-Revised
NHP - Nottingham Health Profile   
PACT - Psychiatric Assessment of Candidates for Transplantation
PLC - Quality of life profile for Chronic Diseases
PSCA - Perception of Self-Care Agency
RSES - Rosenberg Self-Esteem Scale
SCID (DSM-III-R) - The Structured Clinical Interview for DSM-III-R
SCL-90-R - Symptom Checklist 90-Revised
SDS - Symptom Distress Scale
SDS - Zung Self-rating Depression Scale
SF-12 - 12-item Short Form Health Survey [alias: RAND-12]
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]    |  | also see:
SGRQ - St. George's Respiratory Questionnaire   
SIP-136 - Sickness Impact Profile 136
SST - Sniffin’ Sticks Test for olfactory performance
STAI - State-Trait Anxiety Inventory
TAS-20 - Toronto Alexithymia Scale
TICS - Screening Subscale of Chronic Stress of the Trier Inventory for the Assessment of Chronic Stress
TSFQ - Transplant Symptom Frequency Questionnaire
TSI - Transplant Symptom Inventory
TxEQ - Transplant Effects Questionnaire
VAS - Health Status Visual Analog Scale
WCCL - The Ways of Coping Checklist
Zerssen - Zerssen List of Complaints