COSMIN database

A comparative review of health-related quality-of-life measures for use in HIV/AIDS clinical trials

Clayson, D. J., Wild, D. J., Quarterman, P., Duprat-Lomon, I., Kubin, M., and Coons, S. J.
With the advent of highly active antiretroviral therapy (HAART), HIV-infected patients are living longer and are concerned not only with a treatment's ability to extend their life but also with the quality of the life they are able to lead. Regulatory authorities are also paying closer attention to the use of health-related quality-of-life (HR-QOL) measures in clinical trials and to the subsequent claims that are made based on the results. This paper reviews existing HR-QOL measures reported in the HIV/AIDS literature since 1990 and identifies those most worthy of consideration for use in future clinical trials.
Doi 10.2165/00019053-200624080-00003
<Go to ISI>://WOS:000240086500003
Publication year:
General health perceptions / HRQoL:
Health-related quality of life
Adults (18-65)
Seniors (65+)
Certain infections and parasitic diseases and related symptoms
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
2 - Interviews
6 - Clinical rating scales
ACTG-QOL - AIDS Clinical Trial Group QOL Health Survey
AIDS-HAQ - AIDS Health Assessment Questionnaire
COOP/WONCA charts - COOP/WONCA Functional Healh assessment charts   
EORTC QLQ-C30 - European Organization for Research and Treatment of Cancer Quality of Life Questionnaires Core-30 item (versions: EORTC QLQ-C24)   
EQ-5D - EuroQoL-5 Dimensions   
HI - Health Index
HIV-QOL - HIV Quality of Life (versions: HIV-QOL31)
HOPES - Human Immunodeficiency Virus Overview of Problems Evaluation System
HUI - Health Utilities Index
MOS-HIV - Medical Outcomes Study HIV Health Survey
MQoLHIV - Multidimensional Quality of Life for Persons Living with HIV/AIDS
MQOL - McGill Quality of Life Questionnaire [alias: McGill QoL] (also: MQOL-CSF - MQOL-Cardiff Short form)
NHP - Nottingham Health Profile   
QLI - Quality of Life Index [alias: Ferrans and Powers Quality of Life Index]
Q-TWiST - Quality-Adjusted Time Without Symptoms and Toxicities
QWB - Quality of Well-Being Scale
QWB-SA - Quality of Well Being Self-administered Scale
SF-12 - 12-item Short Form Health Survey [alias: RAND-12]
SF-20 - MOS short-form general health survey 20 item
SF-21 - 21 items Short Form Health Survey
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]]    |  | also see:
SF-38 HIV-PARSE - 38 items Short Form Health Survey HIV Patient-Reported Status and Experience
SF-39 - 39 items Short Form Health Survey
SF-56- 56 items Short Form Health Survey
SIP - Sickness Impact Profile   
SWED-QOL - Swedish Health-Related QOL Survey
WHOQOL-BREF - World Health Organization Quality of Life questionnaire–Abbreviated Questionnaire (versions: WHOQOL-HIV-BREF)   
WHOQOL-HIV - WHO Quality of Life-HIV instrument