A review of muscle- and performance-based assessment instruments in DM1
- Abstract:
- INTRODUCTION: Many outcome assessments used in myotonic dystrophy type 1 (DM1) were developed in other populations. Therefore, reliability and validity of these must be established in DM1 populations.
METHODS: A structured literature review was conducted to identify muscle strength and performance-based functional outcome assessments used in DM1 and to review the DM1-specific reliability and validity evidence for those outcome assessments.
RESULTS: Eighteen articles met inclusion criteria and were included in the review. The quantitative muscle testing technique and manual muscle testing were the key assessments of muscle strength. Reliability and validity evidence was also noted for several functional assessments of upper extremity (e.g., Purdue Pegboard Test) and lower extremity function (6-Minute Walk Test).
CONCLUSIONS: This review identified a few measures with encouraging reliability and validity for use in a DM1 populations but highlighted the need for more research. Muscle Nerve 56: 78-85, 2017. - DOI:
- 10.1002/mus.25468
- URL:
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/mus.25468
- Journal:
- Muscle Nerve
- issn:
- 0148-639x
- Publication year:
- 2017
- pages:
- 78-85
- Biological and physiological variables:
- Biological and physiological variables
- Symptom status:
- Physical state
- Functional status:
- Physical functioning
- Age:
- Adults (18-65)
- Disease:
- Congenital malformations, deformations and chromosomal abnormalities and related symptoms
Diseases of and symptoms related to the musculoskeletal system and connective tissue - PRO / non-PRO:
- Non-patient Reported Outcome
- Type of measurement instrument:
- 4 - Performance-based tests
6 - Clinical rating scales
8 - Imaging tests - Instrument:
- 10 meter Max Speed Walk
10MWT - 10 Meter Walk Test (versions: 10MWT under single- and dual-task condition) | 
20 feet walk
6MWT - 6 Minute Walk Test (versions: 6MWT app; 6MWT Lite app; M6MWT - Modified 6MWT; 6mWTPC - 6MWT on parquet and carpet) | | also see: database.cosmin.nl
Assemble peg units
Climb/descend 4 steps
Cutting theraplast
EMG - electromyography
FEV - Forced Expiration Volume
FVC - Forced Vital Capacity
Grip ability
HHD - Hand-Held Dynamometer (Hand-held dynamometry with pulley force sensor)
MIRS - Muscular Impairment Rating Scale
MMT - Manual muscle testing
MRI - Magnetic Resonance Imaging (versions: 2D MRI; 3D MRI; pMRI; sMRI; vMRI; rsMRI)
NIFDS - Neuromuscular Impairment Function and Disability Scale
OLS - One-leg standing balance (alias: OLBT - One Leg Balance Test; 1 leg Balance; OLST - One leg stand test; Single leg stance; SLST - Single Leg Stance Test; Flamingo Balance Test ) (versions: eyes open/closed; OLSTP - OLST prosthesis side)
PPBT - Purdue Pegboard Test
Propelling wheelchair
Standing chair test
Standing from lying
Step test (versions: FSST - 4 square step test; mFSST)
TUG - Timed Up and Go test (versions: TUG 3m) |
Turning blocks