COSMIN database

A review of muscle- and performance-based assessment instruments in DM1

Symonds, T., Campbell, P., and Randall, J. A.
INTRODUCTION: Many outcome assessments used in myotonic dystrophy type 1 (DM1) were developed in other populations. Therefore, reliability and validity of these must be established in DM1 populations.

METHODS: A structured literature review was conducted to identify muscle strength and performance-based functional outcome assessments used in DM1 and to review the DM1-specific reliability and validity evidence for those outcome assessments.

RESULTS: Eighteen articles met inclusion criteria and were included in the review. The quantitative muscle testing technique and manual muscle testing were the key assessments of muscle strength. Reliability and validity evidence was also noted for several functional assessments of upper extremity (e.g., Purdue Pegboard Test) and lower extremity function (6-Minute Walk Test).

CONCLUSIONS: This review identified a few measures with encouraging reliability and validity for use in a DM1 populations but highlighted the need for more research. Muscle Nerve 56: 78-85, 2017.
Muscle Nerve
Publication year:
Biological and physiological variables:
Biological and physiological variables
Symptom status:
Physical state
Functional status:
Physical functioning
Adults (18-65)
Congenital malformations, deformations and chromosomal abnormalities and related symptoms
Diseases of and symptoms related to the musculoskeletal system and connective tissue
PRO / non-PRO:
Non-patient Reported Outcome
Type of measurement instrument:
4 - Performance-based tests
6 - Clinical rating scales
8 - Imaging tests
10-meter Max Speed Walk
10MWT - 10 Meter Walk Test   [see: ZUYD (NL)]
20 feet walk
6MWT - 6-Minute Walk Test   [see: proqolid, ZUYD (NL)]
Assemble peg units
Climb/descend 4 steps
Cutting theraplast
EMG - electromyography
FEV - Forced Expiration Volume
FVC - Forced Vital Capacity
Grip ability
HHD - Hand-Held Dynamometer   [see: ZUYD (NL)]
MIRS - Muscular Impairment Rating Scale
MMT - Manual muscle testing
MRI - Magnetic Resonance Imaging
NIFDS - Neuromuscular Impairment Function and Disability Scale
One-leg standing balance   [see: ZUYD (NL)]
PPBT - Purdue Pegboard Test
Propelling wheelchair
Standing chair test
Standing from lying
Step test
TUG - Timed Up and Go test   [see: ZUYD (NL)]
Turning blocks