Assessment of the construct validity and responsiveness of preference-based quality of life measures in people with Parkinson's: a systematic review
- Xin, Y. and McIntosh, E.
- PURPOSE: Generic preference-based quality of life (PbQoL) measures are sometimes criticized for being insensitive or failing to capture important aspects of quality of life (QoL) in specific populations. The objective of this study was to systematically review and assess the construct validity and responsiveness of PbQoL measures in Parkinson's.
METHODS: Ten databases were systematically searched up to July 2015. Studies were included if a PbQoL instrument along with a common Parkinson's clinical or QoL measure was used, and the utility values were reported. The PbQoL instruments were assessed for construct validity (discriminant and convergent validity) and responsiveness.
RESULTS: Twenty-three of 2758 studies were included, of which the majority evidence was for EQ-5D. Overall good evidence of discriminant validity was demonstrated in the Health Utility Index (HUI)-3, EQ-5D-5L, EQ-5D-3L, 15D, HUI-2, and Disability and Distress Index (DDI). Nevertheless, HUI-2 and EQ-5D-3L were shown to be less sensitive among patients with mild Parkinson's. Moderate to strong correlations were shown between the PbQoL measures (EQ-5D-3L, EQ-5D-5L, 15D, DDI, and HUI-II) and Parkinson's-specific measures. Twelve studies provided evidence for the assessment of responsiveness of EQ-5D-3L and one study for 15D, among which six studies reached inconsistent results between EQ-5D-3L and the Parkinson's-specific measures in measuring the change overtime.
CONCLUSIONS: The construct validity of the PbQoL measures was generally good, but there are concerns regarding their responsiveness to change. In Parkinson's, the inclusion of a Parkinson's-specific QoL measure or a generic but broader scoped mental and well-being focused measure to incorporate aspects not included in the common PbQoL measures is recommended.
- Qual Life Res
- Publication year:
- Overall quality of life:
- Overall quality of life
- Adults (18-65)
- Diseases of and symptoms related to the nervous system
- PRO / non-PRO:
- Patient Reported Outcome
- Type of measurement instrument:
- 1 - Questionnaires
- 15D - 15-Dimensional Health-Related Quality Of Life Measure [see: proqolid]
DDI - Disability and Distress Index (often referred to as the Rosser Index)
EQ-5D-3L - euroQoL 5-dimension 3-level
EQ-5D-5L - euroQoL 5-dimension 5-level
EQ-5D - EuroQoL-5 Dimensions [see: ZUYD (NL)]
EQ-VAS - EuroQol Visual Analogue Scale
HUI-2 - Health Utilities Index Mark 2
HUI-3 - Health Utilities Index-Mark 3
H&Y - Hoehn and Yahr scale
PDQ-39 - Parkinson’s Disease Questionnaire-39-item [see: ZUYD (NL)]
PDQ-8 - Parkinson’s Disease Questionnaire-8-item
PDQL - Parkinson’s Disease Quality of Life questionnaire [see: ZUYD (NL)]
PDQUALIF - Parkinson’s Disease Quality of Life Scale
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: Medical Outcomes Study (MOS) SF-36]] [see: proqolid, ZUYD (NL), also see: https://database.cosmin.nl/?utf8=%E2%9C%93&search_field=all_fields&q=SF-36+-+36-item+Short+Form+Health+Survey++%5Balias%3A+RAND-36%5D%5Balias%3A+Medical+Outcomes+Study+%28MOS%29+SF-36%5D%5D]
UPDRS - Unified Parkinson’s Disease Rating Scale [see: ZUYD (NL)]