COSMIN database

A systematic review of patient-reported outcome measures of neuropathy in children, adolescents and young adults

Johnston, D. L., Sung, L., Stark, D., Frazier, A. L., and Rosenberg, A. R.
PURPOSE: Peripheral neuropathy is an important, yet poorly studied, side effect of pediatric cancer treatment. There are many measures of patient-reported peripheral neuropathy in adults but very few in children. We aimed to systematically review and summarize reliable and valid patient-reported peripheral neuropathy scales used in pediatrics.

METHODS: Four major electronic databases (Medline, Embase, EBSCO Host in Cumulative Index to Nursing and Allied Health Literature, and PsycINFO) were reviewed for studies that measured peripheral neuropathy in pediatric patients. Studies eligible for inclusion were those that described use of any patient-reported scale of peripheral neuropathy among children, adolescents, and young adults with any underlying diagnosis (not limited to cancer).

RESULTS: From a total of 765 articles retrieved, 5 met eligibility criteria and were included. One was a neuropathy symptom score used in patients with diabetes, and the remaining four were in oncology patients and all were based on the total neuropathy score. All involved objective assessments conducted by trained professionals; none relied purely on patient report.

CONCLUSIONS: There are no validated instruments that consist solely of a patient-reported outcome measure of neuropathy in pediatrics and adolescents. Because the clinical evaluation of neuropathy requires specialized training, it is not generalizable in large studies conducted in many diverse institutions. Future studies should validate adult patient-reported neuropathy scales in pediatric and adolescent populations, or develop novel instruments designed for this population.
Support Care Cancer
1433-7339 (Electronic); 0941-4355 (Linking)
Publication year:
Symptom status:
Physical state
Functional status:
Physical functioning
Children (0-18)
Diseases of and symptoms related to the nervous system
Endocrine, nutritional and metabolic diseases and related symptoms
Neoplasms and related symptoms
PRO / non-PRO:
Patient Reported Outcome
Type of measurement instrument:
1 - Questionnaires
NSS - Neuropathy Symptom Score
Ped-mTNS - Pediatric modified Total Neuropathy Score
TNS-PV - Total Neuropathy Score Pediatric Vincristine