Outcome measures in acute gout: a systematic literature review
- Authors:
- Dalbeth, N., Zhong, C. S., Grainger, R., Khanna, D., Khanna, P. P., Singh, J. A., McQueen, F. M., and Taylor, W. J.
- Abstract:
- OBJECTIVE: Five core domains have been endorsed by Outcome Measures in Rheumatology (OMERACT) for acute gout: pain, joint swelling, joint tenderness, patient global assessment, and activity limitation. We evaluated instruments for these domains according to the OMERACT filter: truth, feasibility, and discrimination.
METHODS: A systematic search strategy for instruments used to measure the acute gout core domains was formulated. For each method, articles were assessed by 2 reviewers to summarize information according to the specific components of the OMERACT filter.
RESULTS: Seventy-seven articles and abstracts met the inclusion criteria. Pain was most frequently reported (76 studies, 20 instruments). The pain instruments used most often were 100 mm visual analog scale (VAS) and 5-point Likert scale. Both methods have high feasibility, face and content validity, and within- and between-group discrimination. Four-point Likert scales assessing index joint swelling and tenderness have been used in numerous acute gout studies; these instruments are feasible, with high face and content validity, and show within- and between-group discrimination. Five-point Patient Global Assessment of Response to Treatment (PGART) scales are feasible and valid, and show within- and between-group discrimination. Measures of activity limitations were infrequently reported, and insufficient data were available to make definite assessments of the instruments for this domain.
CONCLUSION: Many different instruments have been used to assess the acute gout core domains. Pain VAS and 5-point Likert scales, 4-point Likert scales of index joint swelling and tenderness and 5-point PGART instruments meet the criteria for the OMERACT filter - DOI:
- URL:
- PM:24334652; http://www.jrheum.org/content/41/3/558.full.pdf
- Journal:
- J Rheumatol.
- issn:
- Publication year:
- 2014
- pages:
- 558-568
- Symptom status:
- Physical state
- Functional status:
- Physical functioning
- General health perceptions / HRQoL:
- Health-related quality of life
- Age:
- Adults (18-65)
Seniors (65+) - Disease:
- Diseases of and symptoms related to the musculoskeletal system and connective tissue
- PRO / non-PRO:
- Non-patient Reported Outcome
Patient Reported Outcome - Type of measurement instrument:
- 1 - Questionnaires
6 - Clinical rating scales - Instrument:
- HAQ - Health Assessment Questionnaire (versions:MHAQ - Modified HAQ; HAQ-II; HAQ-S - HAQ-spondyloarthropathies or HAQ-stiffness; HAQ-Skin; HAQ-pain; HAQ-DI)
Likert Scale
PGA - Patient Global Assessment
PGART - Patient Global Assessment of response to treatment (versions: 5-point numerical scale; 5-point descriptive scale)
Physician measurement of index joint circumference/perimeter
SF-36 - 36-item Short Form Health Survey [alias: RAND-36][alias: MOS SF-36]] (versions: VSF-36 LoA - Visual Version of the SF-36 Limitations of Physical Activities domain; VR-36 - Veterans SF-36) | | also see: database.cosmin.nl
SJC - Swollen Joint Count
TJC - tender joint count (Both clinician and patient reported possible)
VAS - Visual Analogue Scale (versions: vertical; horizontal; 0-10; 0-100)